Principal Research Scientist I - Analytical Development - PDST - Late-Stage Process Analytics Job at AbbVie, Waltham, MA

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  • AbbVie
  • Waltham, MA

Job Description

Principal Research Scientist I will lead analytical activities for a high-throughput testing group supporting biologics process development at late-stage clinical programs. The role requires strong technical expertise in separation-based analytical methods, demonstrated leadership capabilities, and cross-functional collaboration within AbbVie's Operations division.

Responsibilities

  • Lead analytical activities and serve as subject matter expert for separation-based methods within high-throughput testing group
  • Evaluate and select fit-for-purpose analytical technologies; provide technical guidance on method development, execution, and troubleshooting
  • Oversee sample testing schedules, prioritization, and delivery of high-quality results to support process development timelines
  • Support implementation of automation and high-throughput experimentation workflows; drive continuous improvement initiatives
  • Mentor, train, and supervise junior scientists while partnering with process development experts on data interpretation

Requirements

  • PhD in chemistry, biology, biochemistry, chemical engineering, or related discipline with 6+ years analytical development experience; or MS with 10+ years
  • Proven leadership of analytical development activities for mAbs, multi-specifics, antibody-drug conjugates, and fusion proteins
  • Hands-on method development expertise in HPLC, capillary electrophoresis, and protein/impurity analysis techniques
  • Direct people management experience with demonstrated ability to mentor and supervise junior scientists
  • Strong critical thinking, troubleshooting, and problem-solving skills in fast-paced environments
  • Excellent cross-functional communication and interpersonal skills
  • Experience with automation preferred; mass spectrometry and ELISA experience a plus

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