Senior Scientist I, Bioassay Job at Exelixis, Alameda, CA

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  • Exelixis
  • Alameda, CA

Job Description

Senior Scientist I position supporting analytical development for biologic therapeutics at Exelixis. The role involves developing and optimizing cell-based bioassays, potency assays, and functional assays for diverse biologic modalities from concept through qualification and method transfer.

Responsibilities

  • Develop cell-based bioassays and potency assays from concept through optimization, qualification, and transfer
  • Perform mammalian cell culture, transfection, engineered cell model development, and assay optimization
  • Design and troubleshoot functional bioassays including reporter-gene, cytotoxicity, ADCC/CDC, and immune-cell engagement assays
  • Author assay procedures, development reports, qualification documents, and regulatory supporting materials
  • Collaborate with cross-functional teams including Discovery, Process Development, Quality, Regulatory, and external partners on assay strategy

Requirements

  • Ph.D. in cell biology, immunology, molecular biology, biochemistry, or related life sciences discipline
  • Master's degree with 5+ years relevant industry experience, or Bachelor's with 7+ years experience
  • Hands-on experience developing complex cell-based bioassays through optimization, qualification, and method transfer
  • Proficiency with mammalian cell culture, flow cytometry, transient transfection, and plate-based assays
  • Advanced knowledge of potency assay development and biologics CMC analytical control strategy
  • Technical writing skills for protocols, SOPs, development reports, and regulatory documents
  • Strong problem-solving, collaboration, and communication skills in cross-functional environments

Compensation: $127,500 - $180,500 base annually

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